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IBM Db2 12 for z/OS Administrator
- Exam Number/Code : C1000-078
- Exam Name : IBM Db2 12 for z/OS Administrator
- Questions and Answers : 213 Q&As
- Update Time: 2019-01-10
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NEW QUESTION: 1
Refer to the exhibit.
Which option is the received signal power level at the receiver?
A. 0
B. -49.28
C. 1
D. -40.72
Answer: C
NEW QUESTION: 2
Which two items must be created before an organization can be active? (Choose two.)
A. Item Set
B. Primary Vendor
C. Site
D. Financial Period
E. Currency Code
Answer: A,E
NEW QUESTION: 3
What is a Key Performance Indicator of the Strategy to Portfolio value stream?
A. Number of applications or services that require exceptions outside of the existing infrastructure portfolio
B. Number of purchase requests related to purchase order fulfillment
C. Increased uptime for critical business systems
D. Accounting records are produced to show investment and spend in each service
Answer: D
NEW QUESTION: 4
Which of the following statements is true regarding Drug-receptor bonds?
A. Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions
B. Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond
C. Electrostatic bonds are stronger than covalent bonds
D. Covalent bonds of drugs with receptors are strong and mostly reversible
E. Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes
Answer: B
Explanation:
Explanation
Drugs mainly interact with the receptors by means of chemical forces or bonds. There are three major types of drug receptor bonds: - Covalent - Electrostatic - Hydrophobic Covalent bonds are very strong bonds and in most of the cases they are irreversible under biologic conditions. For example, the covalent bond between the acetyl group of aspirin and cyclo-oxygenase enzyme (target enzyme present on the platelets) does not breaks easily. The platelet aggregation effect of aspirin lasts long after free acetyl-salicylic acid has disappeared from the blood (about 15 minutes) and it is reversed only by the synthesis of new cyclo-oxygenase enzyme in new platelets which takes a long time. Hence the effect of aspirin is seen after the drug is stopped. Among the drug receptor interactions, electrostatic bond is much more commonly found than covalent bond. The electrostatic bonds vary from relatively strong linkages between permanently charged ionic molecules to weaker hydrogen bonds and very weak induced dipole interactions such as van der Waals force. The electrostatic bonds are weaker than covalent bonds. Hydrophobic bonds are usually very weak bonds and probably important in the interactions of highly lipid soluble drugs with the lipids of cell membranes and perhaps in the interactions of the drugs with the internal walls of receptor "pockets".